Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors

Bioorg Med Chem Lett. 1999 Nov 1;9(21):3133-6. doi: 10.1016/s0960-894x(99)00538-7.

Abstract

Modifications of our previously reported lead compounds, acyclonucleosides derived from 2,1,3-benzothiadiazine dioxides, in the search for inhibitors of human cytomegalovirus (HCMV), lead us to identify the chlorophenylmethyl benzothiadiazine dioxides derivatives as potent HCMV inhibitors. The synthesis and antiviral data of this second-generation of benzothiadiazine dioxide compounds are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology
  • Benzothiadiazines / chemical synthesis*
  • Benzothiadiazines / pharmacology
  • Cytomegalovirus / drug effects*
  • Humans
  • Molecular Structure
  • Nucleosides / chemical synthesis*
  • Nucleosides / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-Infective Agents
  • Benzothiadiazines
  • Nucleosides