Abstract
We have cloned three sox genes in zebrafish (Danio rerio), one related to human and chicken SOX21, and two related to mammalian and chicken Sox-11. Zebrafish sox21, sox11A and sox11B transcripts are accumulated in the egg, are present in all cells until gastrulation and become restricted later to the developing central nervous system (CNS); expression in adults is undetectable. sox21 is expressed in the forebrain, midbrain and hindbrain, but maximally at the midbrain-hindbrain junction; sox11A,B have a widespread and dynamic expression in the CNS, but in contrast to sox21 are absent at the midbrain-hindbrain boundary.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Blastocyst
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Brain / embryology
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Cloning, Molecular
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Embryo, Nonmammalian
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Gene Expression Regulation, Developmental*
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High Mobility Group Proteins / genetics*
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High Mobility Group Proteins / metabolism
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Molecular Sequence Data
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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SOX Transcription Factors
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SOXC Transcription Factors
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Sequence Homology, Amino Acid
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Transcription, Genetic
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Zebrafish / embryology*
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Zebrafish / genetics*
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Zebrafish Proteins*
Substances
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High Mobility Group Proteins
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Neoplasm Proteins
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SOX Transcription Factors
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SOXC Transcription Factors
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Sox11 protein, mouse
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Zebrafish Proteins
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sox11a protein, zebrafish
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sox11b protein, zebrafish
Associated data
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GENBANK/U85090
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GENBANK/U85091
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GENBANK/U85092