Bilateral subdural haematomas following lumbar puncture in three haematopoietic stem cell transplant recipients

P Hentschke; H Hägglund; J Mattsson; S Carlens; B Lönnqvist; P Ljungman; J Aschan; S Fredrikson; O Ringdén

doi:10.1038/sj.bmt.1702018

Bilateral subdural haematomas following lumbar puncture in three haematopoietic stem cell transplant recipients

Bone Marrow Transplant. 1999 Nov;24(9):1033-5. doi: 10.1038/sj.bmt.1702018.

Authors

P Hentschke¹, H Hägglund, J Mattsson, S Carlens, B Lönnqvist, P Ljungman, J Aschan, S Fredrikson, O Ringdén

Affiliation

¹ Centre for Allogeneic Stem Cell Transplantation, Huddinge Hospital, Stockholm, Sweden.

PMID: 10556965
DOI: 10.1038/sj.bmt.1702018

Abstract

Between 1990 and 1996, three patients (1.1%), all with CML, among 272 patients with haematological malignancies, developed bilateral subdural haematomas (SDH) after treatment with i.t. MTX before HSCT in our unit. Since October 1996, we have given i.t. MTX only to patients at increased risk of CNS leukaemia such as ALL and AML M4 or M5. We suggest that intrathecal treatment before HSCT should only be given to patients at increased risk of CNS leukaemia.

Publication types

Case Reports

MeSH terms

Adult
Antimetabolites, Antineoplastic / administration & dosage
Antimetabolites, Antineoplastic / adverse effects
Hematoma, Subdural / diagnostic imaging
Hematoma, Subdural / etiology*
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
Male
Methotrexate / administration & dosage
Methotrexate / adverse effects
Middle Aged
Risk Factors
Spinal Puncture / adverse effects*
Tomography, X-Ray Computed

Substances

Antimetabolites, Antineoplastic
Methotrexate