Bacterial two-component signalling as a therapeutic target in drug design. Inhibition of NRII by the diphenolic methanes (bisphenols)

Adv Exp Med Biol. 1998:456:269-86. doi: 10.1007/978-1-4615-4897-3_14.

Authors

J M Domagala¹, D Alessi, M Cummings, S Gracheck, L Huang, M Huband, G Johnson, E Olson, M Shapiro, R Singh, Y Song, R Van Bogelen, D Vo, S Wold

Affiliation

¹ Chemistry Department, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA.

PMID: 10549373
DOI: 10.1007/978-1-4615-4897-3_14

No abstract available

Publication types

Review

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Bacteria / drug effects*
Bacterial Proteins / antagonists & inhibitors*
Drug Design*
Drug Resistance, Microbial*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Escherichia coli / drug effects
Escherichia coli / enzymology
Histidine Kinase
Humans
Molecular Structure
PII Nitrogen Regulatory Proteins
Phenols / chemistry*
Phenols / pharmacology
Protein Kinase Inhibitors
Protein Kinases*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Enzyme Inhibitors
PII Nitrogen Regulatory Proteins
Phenols
Protein Kinase Inhibitors
PIID regulatory protein, Bacteria
Protein Kinases
Histidine Kinase