Abstract
Semisynthetic derivatives were prepared from two natural annonaceous acetogenins, rolliniastatin-1 and squamocin, and their cytotoxicity was evaluated. Amino derivatives show decreased bioactivity. Isorolliniastatin-1 was found to be much less toxic than rolliniastatin-1 after intraperitoneal administration to mice, although the in vitro cytotoxicity of both compounds was comparable.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Furans / administration & dosage
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Furans / chemical synthesis*
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Furans / chemistry
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Furans / pharmacology*
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Humans
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Injections, Intraperitoneal
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Lactones / administration & dosage
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Lactones / chemical synthesis*
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Lactones / chemistry
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Lactones / pharmacology*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Furans
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Lactones
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isomurisolenin