2-Naphthylcarbapenems: broad spectrum antibiotics with enhanced potency against MRSA

M L Greenlee; F DiNinno; J J Herrmann; C Jaworsky; D A Muthard; T N Salzmann

doi:10.1016/s0960-894x(99)00500-4

2-Naphthylcarbapenems: broad spectrum antibiotics with enhanced potency against MRSA

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2893-6. doi: 10.1016/s0960-894x(99)00500-4.

Authors

M L Greenlee¹, F DiNinno, J J Herrmann, C Jaworsky, D A Muthard, T N Salzmann

Affiliation

¹ Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

PMID: 10522713
DOI: 10.1016/s0960-894x(99)00500-4

Abstract

A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum of gram-negative activity.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology
Carbapenems / chemical synthesis*
Carbapenems / pharmacology
Dipeptidases / metabolism
Methicillin Resistance*
Molecular Structure
Naphthalenes / chemical synthesis*
Naphthalenes / pharmacology
Staphylococcus / drug effects*

Substances

Anti-Bacterial Agents
Carbapenems
Naphthalenes
Dipeptidases
dipeptidase