Abstract
Straight chain compounds having a phenylisoserine unit and an oxetane ring at the alpha- and omega- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.
MeSH terms
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Alcohols / chemistry
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Antineoplastic Agents, Phytogenic / chemistry*
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Chemical Phenomena
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Chemistry, Physical
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Ethers, Cyclic / chemistry*
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Magnetic Resonance Spectroscopy
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Paclitaxel / chemistry*
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Serine / analogs & derivatives*
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Serine / chemistry
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Tubulin / chemistry
Substances
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Alcohols
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Antineoplastic Agents, Phytogenic
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Ethers, Cyclic
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Tubulin
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Serine
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beta-phenylisoserine
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oxetane
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Paclitaxel