Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection

J Virol. 1999 Nov;73(11):9604-8. doi: 10.1128/JVI.73.11.9604-9608.1999.

Abstract

Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

MeSH terms

  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Amino Acid Sequence
  • Capsid / chemistry
  • Capsid / genetics
  • Chronic Disease
  • DNA Virus Infections / virology*
  • DNA Viruses / chemistry
  • DNA Viruses / classification
  • DNA Viruses / genetics*
  • DNA, Viral / genetics
  • Evolution, Molecular
  • Female
  • Hepatitis Viruses / chemistry
  • Hepatitis Viruses / classification
  • Hepatitis Viruses / genetics*
  • Hepatitis, Viral, Human / virology*
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data

Substances

  • DNA, Viral

Associated data

  • GENBANK/AB026345
  • GENBANK/AB026346
  • GENBANK/AB026347
  • GENBANK/AB026348
  • GENBANK/AB026349
  • GENBANK/AB026350
  • GENBANK/AB026351
  • GENBANK/AB026352
  • GENBANK/AB026353
  • GENBANK/AB026354
  • GENBANK/AB026355
  • GENBANK/AB026356
  • GENBANK/AB026357
  • GENBANK/AB026358
  • GENBANK/AB026359
  • GENBANK/AB026360
  • GENBANK/AB026361
  • GENBANK/AB026362
  • GENBANK/AB026363
  • GENBANK/AB026364
  • GENBANK/AB026365
  • GENBANK/AB026366
  • GENBANK/AB026367
  • GENBANK/AB026368
  • GENBANK/AB026369
  • GENBANK/AB026370
  • GENBANK/AB026371
  • GENBANK/AB026372
  • GENBANK/AB026373
  • GENBANK/AB026374