[The effect of selective m-cholinopositive substances on the antiparkinson activity of atropine]

A V Khrabrova; A B Kosmachev; T A Titkova; A G Chigarev

[The effect of selective m-cholinopositive substances on the antiparkinson activity of atropine]

Eksp Klin Farmakol. 1999 Jul-Aug;62(4):7-8.

[Article in Russian]

Authors

A V Khrabrova¹, A B Kosmachev, T A Titkova, A G Chigarev

Affiliation

¹ Institute of Toxicology, Russian Federation Ministry of Public Health, St. Petersburg, Russia.

PMID: 10513326

Abstract

The effect of the selectivity of cholinopositive compounds on atropin antiparkinsonian activity was compared in experiments on rats. The selectivity of the effect of two new synthesized cholinopositive compounds of the phenylcarbamate group was evaluated in preliminary experiments. It was determined by means of these compounds that stimulation of m1-cholinoceptors reduces while stimulation of m2-cholinoceptors has no effect on the ability of atropin to prevent haloperidol-induced catalepsy.

Publication types

Comparative Study
English Abstract

MeSH terms

Animals
Antiparkinson Agents / pharmacology*
Antiparkinson Agents / therapeutic use
Atropine / pharmacology*
Atropine / therapeutic use
Benzene Derivatives / pharmacology*
Catalepsy / chemically induced
Catalepsy / drug therapy
Cholinesterase Inhibitors / pharmacology*
Drug Evaluation, Preclinical
Drug Interactions
Haloperidol
Rats
Receptors, Muscarinic / drug effects

Substances

Antiparkinson Agents
Benzene Derivatives
Cholinesterase Inhibitors
Receptors, Muscarinic
Atropine
Haloperidol