Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity

AJNR Am J Neuroradiol. 1999 Sep;20(8):1507-10.

Abstract

Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Sickle Cell / drug therapy
  • Bone Marrow Transplantation
  • Brain / drug effects
  • Brain / pathology
  • Brain Mapping*
  • Child
  • Child, Preschool
  • Cyclosporine / administration & dosage
  • Cyclosporine / adverse effects*
  • Diffusion
  • Humans
  • Image Processing, Computer-Assisted*
  • Immunosuppressive Agents / adverse effects*
  • Magnetic Resonance Imaging*
  • Male
  • Neurotoxicity Syndromes / diagnosis*
  • Severe Combined Immunodeficiency / drug therapy

Substances

  • Immunosuppressive Agents
  • Cyclosporine