Synthesis of N-[4-(alkyl)cyclohexyl]-substituted benzamides with anti-inflammatory and analgesic activities

Farmaco. 1999 Aug 30;54(8):524-32. doi: 10.1016/s0014-827x(99)00057-9.

Abstract

Two series of N-[4-(alkyl)cyclohexyl]-substituted benzamides, i.e. a series of N-[4-(tert-butyl)cyclohexyl]-substituted benzamides and a series of N-[4-(ethyl)cyclohexyl]-substituted benzamides, were synthesised and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Benzamides / chemical synthesis*
  • Benzamides / pharmacology
  • Benzamides / toxicity
  • Carrageenan
  • Chemical Phenomena
  • Chemistry, Physical
  • Edema / chemically induced
  • Edema / prevention & control
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Pain Measurement / drug effects
  • Pregnancy
  • Rats
  • Spectrophotometry, Infrared
  • Stomach Ulcer / chemically induced

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzamides
  • Carrageenan