Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles

A N Pae; H Y Kim; H J Joo; B H Kim; Y S Cho; K I Choi; J H Choi; H Y Koh

doi:10.1016/s0960-894x(99)00473-4

Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2679-84. doi: 10.1016/s0960-894x(99)00473-4.

Authors

A N Pae¹, H Y Kim, H J Joo, B H Kim, Y S Cho, K I Choi, J H Choi, H Y Koh

Affiliation

¹ Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.

PMID: 10509915
DOI: 10.1016/s0960-894x(99)00473-4

Abstract

Two series of oxazolidinone derivatives having substituted isoxazoles were synthesized and tested for antibacterial activities against several Gram-positive strains including the resistant strains of Staphylococcus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed in vitro activities (MIC) comparable or superior to the reference compound vancomycin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Gram-Positive Bacteria / drug effects
Isoxazoles / chemistry*
Microbial Sensitivity Tests
Oxazoles / chemical synthesis*
Oxazoles / chemistry
Oxazoles / pharmacology*

Substances

Anti-Bacterial Agents
Isoxazoles
Oxazoles