T cells work together to fight cancer

Curr Biol. 1999 Sep 23;9(18):R695-7. doi: 10.1016/s0960-9822(99)80442-4.

Abstract

Recent studies have identified new melanoma antigens that are recognised by CD4(+) T cells. Analysis of tumour-specific CD4(+) T-cell responses may lead to the development of optimal anti-cancer vaccines that can induce an orchestrated effort of tumour-specific CD4(+) and CD8(+) T cells in the fight against cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Cancer Vaccines / immunology
  • Histocompatibility Antigens Class II / immunology
  • Immunologic Surveillance
  • Melanoma / immunology
  • Mice
  • Models, Immunological
  • Neoplasms / immunology*
  • Neoplasms / prevention & control
  • Neoplasms / therapy
  • Neoplasms, Experimental / immunology

Substances

  • Antigens, Neoplasm
  • Cancer Vaccines
  • Histocompatibility Antigens Class II