Abstract
HIV-positive plasma samples from patients with and without neuropathy and with high titre anti-GalS antibodies showed strong binding to the myelin membrane of both fixed and unfixed human sciatic nerve specimens. This staining pattern was also seen with a plasma sample from a patient with IgM paraproteinaemic inflammatory demyelinating neuropathy with anti-GalS IgM antibody. Teased nerve fibres incubated with these anti-GalS antibodies from both HIV and non-HIV plasma samples showed immunofluorescence at the paranodal regions and Schmidt-Lanterman incisures. These data support a potential role for these antibodies in the aetiology of HIV-associated immune mediated neuropathies.
MeSH terms
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Demyelinating Diseases / etiology
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Demyelinating Diseases / immunology
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Demyelinating Diseases / metabolism*
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Demyelinating Diseases / pathology
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Fluorescent Antibody Technique
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Glycolipids / immunology
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HIV Antibodies / metabolism*
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HIV Infections / complications
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HIV Infections / immunology*
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HIV Infections / metabolism*
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HIV Infections / pathology
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Humans
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Immunohistochemistry
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Nerve Fibers / immunology
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Nerve Fibers / metabolism
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Nerve Fibers / pathology
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Paraffin Embedding
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Peripheral Nervous System Diseases / etiology
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Peripheral Nervous System Diseases / immunology
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Peripheral Nervous System Diseases / metabolism*
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Peripheral Nervous System Diseases / pathology
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Protein Binding
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Sciatic Nerve / metabolism
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Sciatic Nerve / pathology
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Sulfoglycosphingolipids / immunology*
Substances
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Glycolipids
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HIV Antibodies
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Sulfoglycosphingolipids