Abstract
Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.
MeSH terms
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Antigens, CD / immunology
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Antigens, Neoplasm / immunology
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Cytotoxicity, Immunologic*
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Flow Cytometry
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Humans
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Killer Cells, Natural / immunology*
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Lectins, C-Type*
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Melanoma / immunology*
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Membrane Glycoproteins / immunology
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NK Cell Lectin-Like Receptor Subfamily C
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NK Cell Lectin-Like Receptor Subfamily D
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Receptors, Antigen, T-Cell / immunology*
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Receptors, Immunologic / immunology*
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Receptors, Natural Killer Cell
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antigens, CD
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Antigens, Neoplasm
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KLRC1 protein, human
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KLRD1 protein, human
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Lectins, C-Type
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Membrane Glycoproteins
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NK Cell Lectin-Like Receptor Subfamily C
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NK Cell Lectin-Like Receptor Subfamily D
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Receptors, Antigen, T-Cell
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Receptors, Immunologic
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Receptors, Natural Killer Cell