Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors

L Chan; H Jin; T Stefanac; W Wang; J F Lavallée; J Bédard; S May

doi:10.1016/s0960-894x(99)00435-7

Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors

Bioorg Med Chem Lett. 1999 Sep 6;9(17):2583-6. doi: 10.1016/s0960-894x(99)00435-7.

Authors

L Chan¹, H Jin, T Stefanac, W Wang, J F Lavallée, J Bédard, S May

Affiliation

¹ BioChem Pharma Inc., Québec Canada.

PMID: 10498213
DOI: 10.1016/s0960-894x(99)00435-7

Abstract

Structure-activity relationship studies on our newly identified anti-HCMV compounds, the 1,6-naphthyridines led to the identification of isoquinoline-6-carboxamides as potent and selective anti-HCMV agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Cytomegalovirus / drug effects*
Isoquinolines / chemistry
Isoquinolines / pharmacology*
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

Antiviral Agents
Isoquinolines