Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study

R Soliva; F J Luque; C Alhambra; M Orozco

doi:10.1080/07391102.1999.10508343

Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study

J Biomol Struct Dyn. 1999 Aug;17(1):89-99. doi: 10.1080/07391102.1999.10508343.

Authors

R Soliva¹, F J Luque, C Alhambra, M Orozco

Affiliation

¹ Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Spain.

PMID: 10496424
DOI: 10.1080/07391102.1999.10508343

Abstract

State of the art molecular dynamic simulations show that simple modification of the sugar puckering of 2'deoxyriboses leads to a reversible change between two stable forms of DNA which resemble very closely the canonical A and B duplex forms. Analysis of the A-type and B-type structures reveals interesting, and previously unknown features of these two families of conformations of the DNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrates / chemistry*
Computer Simulation
DNA / chemistry*
Models, Molecular
Nucleic Acid Conformation*
Solutions

Substances

Carbohydrates
Solutions
DNA