Inappropriate antidiuretic hormone secretion after high-dose thiotepa

S Sica; S Cicconi; F Sorà; P Chiusolo; N Piccirillo; L Laurenti; E O La Barbera; G Giordano; G Leone

doi:10.1038/sj.bmt.1701922

Inappropriate antidiuretic hormone secretion after high-dose thiotepa

Bone Marrow Transplant. 1999 Sep;24(5):571-2. doi: 10.1038/sj.bmt.1701922.

Authors

S Sica¹, S Cicconi, F Sorà, P Chiusolo, N Piccirillo, L Laurenti, E O La Barbera, G Giordano, G Leone

Affiliation

¹ Divisione Ematologia, Istituto di Semeiotica Medica, Università Cattolica Sacro Cuore, Rome, Italy.

PMID: 10482945
DOI: 10.1038/sj.bmt.1701922

Abstract

High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain Neoplasms / drug therapy
Brain Neoplasms / radiotherapy
Brain Neoplasms / therapy
Combined Modality Therapy
Cranial Irradiation
Female
Hematopoietic Stem Cell Transplantation
Humans
Inappropriate ADH Syndrome / chemically induced*
Lymphoma, Non-Hodgkin / drug therapy
Lymphoma, Non-Hodgkin / radiotherapy
Lymphoma, Non-Hodgkin / therapy
Thiotepa / administration & dosage
Thiotepa / adverse effects*
Transplantation Conditioning / adverse effects*

Substances

Thiotepa