In vitro antitrypanosomal activity of Moringa stenopetala leaves and roots

Phytother Res. 1999 Sep;13(6):538-9. doi: 10.1002/(sici)1099-1573(199909)13:6<538::aid-ptr486>3.0.co;2-k.

Abstract

The leaves and the root extracts of Moringa stenopetala were tested in vitro against trypomastigotes of Trypanosoma brucei, Trypanosoma cruzi and L. donovani amastigotes. The fresh root wood ethanol extract and the dried leaves acetone extract were found to be active against T. brucei with an ED(50) value of 9.2 microg/mL and 10.0 microg/mL respectively. All the other extracts were inactive against all the tested parasite forms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chlorocebus aethiops
  • Cricetinae
  • Leishmania donovani / isolation & purification*
  • Mesocricetus
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Plant Roots
  • Plants, Edible*
  • Plants, Medicinal*
  • Spleen / parasitology
  • Trypanocidal Agents / pharmacology*
  • Trypanosoma brucei brucei / drug effects*
  • Trypanosoma cruzi / drug effects*
  • Vero Cells

Substances

  • Plant Extracts
  • Trypanocidal Agents