Abstract
Two novel trimers, triscutins A and B (1 and 2), based on pristimerin triterpene units, were isolated and characterized from Maytenus scutioides. Their structures were determined on the basis of spectroscopic evidence, including 1H-13C heteronuclear correlation (HMQC), long-range correlation with inverse detection (HMBC), and ROESY NMR experiments; and their absolute configurations, by means of CD studies. Compounds 1 and 2 were assayed for antimicrobial and cytotoxic activities, and their possible biosynthetic route is proposed.
MeSH terms
-
Anti-Bacterial Agents
-
Anti-Infective Agents / isolation & purification*
-
Anti-Infective Agents / pharmacology
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Bacteria / drug effects
-
Candida / drug effects
-
Circular Dichroism
-
Drug Screening Assays, Antitumor
-
HeLa Cells
-
Humans
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Plants, Medicinal / chemistry*
-
South America
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology
-
Tumor Cells, Cultured
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents
-
Antineoplastic Agents, Phytogenic
-
Triterpenes
-
triscutin A
-
triscutin B