Isolation of two highly methylated polyketide derivatives from a yew-associated penicillium species

DB Stierle; AA Stierle; BK Ganser

doi:10.1021/np980510v

Isolation of two highly methylated polyketide derivatives from a yew-associated penicillium species

J Nat Prod. 1999 Aug;62(8):1147-50. doi: 10.1021/np980510v.

Authors

DB Stierle¹, AA Stierle, BK Ganser

Affiliation

¹ Department of Chemistry, Montana Tech of the University of Montana, Butte, Montana 59701, USA.

PMID: 10479323
DOI: 10.1021/np980510v

Abstract

Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structures of these highly methylated polyketide derivatives were deduced by detailed analysis of both 1D and 2D NMR and difference NOE spectra. Both compounds were active against the plant pathogen, Sclerotinia sclerotiorum in the standard disk assay.