Orizabins V-VIII, tetrasaccharide glycolipids from the Mexican scammony root (Ipomoea orizabensis)

J Nat Prod. 1999 Aug;62(8):1096-100. doi: 10.1021/np9900627.

Abstract

An extensive investigation of the so-called jalapin resinoid obtained from roots of the Mexican scammony, Ipomoea orizabensis, using high field NMR spectroscopy led to the characterization of six glycosides, including the known scammonins I (1) and II (2) and four new tetrasaccharides of jalapinolic acid, orizabins V-VIII (3-6). All the isolates (1-6) were found to be weakly cytotoxic toward human oral epidermoid carcinoma (KB).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carbohydrate Sequence
  • Drug Screening Assays, Antitumor
  • Glycolipids / isolation & purification*
  • Glycolipids / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mexico
  • Molecular Sequence Data
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Polysaccharides / isolation & purification*
  • Polysaccharides / pharmacology
  • Spectrometry, Mass, Fast Atom Bombardment
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycolipids
  • Polysaccharides