Abstract
An extensive investigation of the so-called jalapin resinoid obtained from roots of the Mexican scammony, Ipomoea orizabensis, using high field NMR spectroscopy led to the characterization of six glycosides, including the known scammonins I (1) and II (2) and four new tetrasaccharides of jalapinolic acid, orizabins V-VIII (3-6). All the isolates (1-6) were found to be weakly cytotoxic toward human oral epidermoid carcinoma (KB).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Carbohydrate Sequence
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Drug Screening Assays, Antitumor
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Glycolipids / isolation & purification*
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Glycolipids / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Mexico
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Molecular Sequence Data
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Polysaccharides / isolation & purification*
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Polysaccharides / pharmacology
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Spectrometry, Mass, Fast Atom Bombardment
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Glycolipids
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Polysaccharides