Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2325-8. doi: 10.1016/s0960-894x(99)00382-0.

Abstract

Efficient syntheses of ent-isozonarol (6a), ent-isozonarone (7a) and ent-chromazonarol (8) from (-)-sclareol (12) are described. 6a and 7a show a significative antitumoral activity.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Marine Biology
  • Tumor Cells, Cultured
  • Xanthenes / chemical synthesis*
  • Xanthenes / chemistry
  • Xanthenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Xanthenes
  • chromazonarol