Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

M Medarde; A C Ramos; E Caballero; R Peláez-Lamamié de Clairac; J L López; D G Grávalos; A S Feliciano

doi:10.1016/s0960-894x(99)00370-4

Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2303-8. doi: 10.1016/s0960-894x(99)00370-4.

Authors

M Medarde¹, A C Ramos, E Caballero, R Peláez-Lamamié de Clairac, J L López, D G Grávalos, A S Feliciano

Affiliation

¹ Lab. de Química Orgánica y Farmacéutica. Fac. Farmacia, Salamanca, Spain. medarde@gugu.usal.es

PMID: 10476858
DOI: 10.1016/s0960-894x(99)00370-4

Abstract

Taking into account the structure of Combretastatins, we have synthesized and assayed for cytotoxic activity of new indole derivatives. Two aryl groups are maintained in the cis orientation required for activity by means of an indole moiety built up on less active ketoderivatives used as starting materials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Bibenzyls / chemical synthesis*
Bibenzyls / chemistry
Bibenzyls / pharmacology*
Drug Screening Assays, Antitumor
Humans
Stilbenes*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Bibenzyls
Stilbenes
combretastatin