Abstract
The increased life span caused by certain mutations in the nematode Caenorhabditis elegans has been interpreted in terms of two metabolic theories of ageing: the oxidative damage theory and the rate of living theory. New findings support the former, but not the latter interpretation.
MeSH terms
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Aging / metabolism
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Aging / physiology*
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Animals
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans / physiology*
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Caenorhabditis elegans Proteins*
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Cell Nucleus / metabolism
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Helminth Proteins / genetics
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Helminth Proteins / metabolism
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Longevity
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Mitochondria / chemistry
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Mitochondria / metabolism
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Mutation
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Oxygen Consumption / physiology
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Phosphatidylinositol 3-Kinases*
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Receptor, Insulin / genetics
Substances
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CLK-1 protein, C elegans
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Caenorhabditis elegans Proteins
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Helminth Proteins
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Phosphatidylinositol 3-Kinases
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AGE-1 protein, C elegans
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DAF-2 protein, C elegans
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Receptor, Insulin