Nematode ageing: Putting metabolic theories to the test

Curr Biol. 1999 Aug 26;9(16):R614-6. doi: 10.1016/s0960-9822(99)80387-x.

Abstract

The increased life span caused by certain mutations in the nematode Caenorhabditis elegans has been interpreted in terms of two metabolic theories of ageing: the oxidative damage theory and the rate of living theory. New findings support the former, but not the latter interpretation.

MeSH terms

  • Aging / metabolism
  • Aging / physiology*
  • Animals
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins*
  • Cell Nucleus / metabolism
  • Helminth Proteins / genetics
  • Helminth Proteins / metabolism
  • Longevity
  • Mitochondria / chemistry
  • Mitochondria / metabolism
  • Mutation
  • Oxygen Consumption / physiology
  • Phosphatidylinositol 3-Kinases*
  • Receptor, Insulin / genetics

Substances

  • CLK-1 protein, C elegans
  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Phosphatidylinositol 3-Kinases
  • AGE-1 protein, C elegans
  • DAF-2 protein, C elegans
  • Receptor, Insulin