Abstract
A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-beta-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adjuvants, Immunologic / chemical synthesis*
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Adjuvants, Immunologic / metabolism
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Animals
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Antibody Formation / drug effects
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Cytokines / metabolism
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Glucosamine / analogs & derivatives*
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Glucosamine / chemical synthesis
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Glucosamine / pharmacology
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Humans
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Monocytes / drug effects
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Monocytes / metabolism
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Nitric Oxide Synthase / metabolism
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Nitric Oxide Synthase Type II
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Rabbits
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Structure-Activity Relationship
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Sugar Phosphates / chemical synthesis*
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Sugar Phosphates / pharmacology
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Tetanus Toxoid / immunology
Substances
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Adjuvants, Immunologic
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Cytokines
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Sugar Phosphates
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Tetanus Toxoid
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NOS2 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse
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Glucosamine