Abstract
The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Humans
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NADH, NADPH Oxidoreductases / drug effects
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NADH, NADPH Oxidoreductases / genetics
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NADH, NADPH Oxidoreductases / metabolism*
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Quinolones / chemical synthesis*
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Quinolones / chemistry
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Quinolones / pharmacology
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Recombinant Proteins / drug effects
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Recombinant Proteins / metabolism
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Structure-Activity Relationship
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Substrate Specificity
Substances
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Antineoplastic Agents
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Quinolones
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Recombinant Proteins
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NADH, NADPH Oxidoreductases