Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages

R Manjeet K; B Ghosh

doi:10.1016/s0192-0561(99)00024-7

Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages

Int J Immunopharmacol. 1999 Jul;21(7):435-43. doi: 10.1016/s0192-0561(99)00024-7.

Authors

R Manjeet K¹, B Ghosh

Affiliation

¹ Molecular Immunology and Immunogenetics Laboratory, Centre for Biochemical Technology, Delhi University Campus, India.

PMID: 10454017
DOI: 10.1016/s0192-0561(99)00024-7

Abstract

High amounts of nitric oxide and TNF-alpha generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-alpha and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Female
Lipopolysaccharides / antagonists & inhibitors*
Lipopolysaccharides / pharmacology
Macrophage Activation / drug effects
Macrophages / drug effects*
Macrophages / metabolism*
Mice
Nitric Oxide / biosynthesis*
Quercetin / pharmacology*
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / biosynthesis

Substances

Lipopolysaccharides
Tumor Necrosis Factor-alpha
Nitric Oxide
Quercetin