Abstract
Mimetics of Neu5Ac2en and KDN2en, based on delta4-beta-delta-glucopyranosiduronic acids, have been synthesised. The Neu5Ac2en mimetic 5 showed inhibition of both bacterial and viral sialidases, with inhibition of the viral sialidase being comparable to that of Neu5Ac2en itself.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Glucuronates / chemical synthesis*
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Glucuronates / pharmacology*
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Influenza A virus / enzymology
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Molecular Mimicry
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N-Acetylneuraminic Acid / analogs & derivatives
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N-Acetylneuraminic Acid / chemistry
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Neuraminidase / antagonists & inhibitors*
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Ostreidae / enzymology
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Salmonella typhimurium / enzymology
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Sialic Acids / chemistry
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Sialic Acids / metabolism
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Structure-Activity Relationship
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Vibrio cholerae / enzymology
Substances
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2-deoxy-2,3-didehydro-D-glycero-D-galacto-2-nonulopyranosonic acid
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Enzyme Inhibitors
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Glucuronates
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Sialic Acids
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2-deoxy-2,3-dehydro-N-acetylneuraminic acid
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Neuraminidase
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N-Acetylneuraminic Acid