Abstract
We report on a rare fatal case of postoperative toxic shock syndrome caused by infection with a highly virulent methicillin-resistant Staphylococcus aureus strain, designated Sak-1, which was found to be characteristic in its increased production of toxic shock syndrome toxin 1 in human whole blood (about 30-fold more than produced in Tod Hewitt broth). The strain also produced a high level of toxic shock syndrome toxin 1 in the circulating blood of mice experimentally infected with the strain.
MeSH terms
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Adult
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Animals
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Bacterial Toxins*
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Enterotoxins / biosynthesis
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Fatal Outcome
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Humans
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Male
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Methicillin Resistance*
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Mice
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Postoperative Complications / microbiology*
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Shock, Septic / microbiology*
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / isolation & purification
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Staphylococcus aureus / metabolism
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Staphylococcus aureus / pathogenicity*
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Superantigens*
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Virulence
Substances
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Bacterial Toxins
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Enterotoxins
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Superantigens
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enterotoxin F, Staphylococcal