In the present paper it was reported that 24 cases of ulcerative colitis and 23 cases of chronic colitis were treated by drug-separated moxibustion and the total effective rates were 95.83% and 95.65% respectively, which were markedly superior to that of western medicine group. Observation in 15 cases of ulcerative colitis showed that drug-separated moxibustion could inhibit humoral immunity and elevate cellular immune function. The therapy possibly regulated the abnormal ratio of T-lymphocyte subgroups and corrected the abnormal state of autoimmunity of patients, so that pathological changes of intestinal mucosa were corrected effectively.