New hexahydrocarbazoles and spiro indoles, and their affinity for D2 dopamine and 5-HT2A serotonin receptors

Chem Pharm Bull (Tokyo). 1999 Jul;47(7):1006-9. doi: 10.1248/cpb.47.1006.

Abstract

In a search for novel atypical antipsychotics, the synthesis of new hexahydrocarbazoles and spiro indoles N-substituted with a 3-(dimethylamino)propyl chain is described, together with the results of an in vitro evaluation of their affinities for D2 and 5-HT2A receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antipsychotic Agents / chemical synthesis*
  • Antipsychotic Agents / metabolism
  • Antipsychotic Agents / pharmacology
  • Binding, Competitive / drug effects
  • Carbazoles / chemical synthesis*
  • Carbazoles / pharmacology
  • Dopamine Antagonists / metabolism
  • In Vitro Techniques
  • Indoles / chemical synthesis*
  • Indoles / pharmacology
  • Ketanserin / pharmacokinetics
  • Neostriatum / drug effects
  • Neostriatum / metabolism
  • Prefrontal Cortex / drug effects
  • Prefrontal Cortex / metabolism
  • Rats
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Dopamine D2 / drug effects
  • Receptors, Dopamine D2 / metabolism*
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / metabolism*
  • Serotonin Antagonists / pharmacokinetics
  • Spiperone / metabolism

Substances

  • Antipsychotic Agents
  • Carbazoles
  • Dopamine Antagonists
  • Indoles
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Dopamine D2
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Spiperone
  • Ketanserin