Abstract
In a search for novel atypical antipsychotics, the synthesis of new hexahydrocarbazoles and spiro indoles N-substituted with a 3-(dimethylamino)propyl chain is described, together with the results of an in vitro evaluation of their affinities for D2 and 5-HT2A receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antipsychotic Agents / chemical synthesis*
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Antipsychotic Agents / metabolism
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Antipsychotic Agents / pharmacology
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Binding, Competitive / drug effects
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Carbazoles / chemical synthesis*
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Carbazoles / pharmacology
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Dopamine Antagonists / metabolism
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In Vitro Techniques
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Ketanserin / pharmacokinetics
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Neostriatum / drug effects
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Neostriatum / metabolism
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Prefrontal Cortex / drug effects
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Prefrontal Cortex / metabolism
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Rats
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Receptor, Serotonin, 5-HT2A
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Receptors, Dopamine D2 / drug effects
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Receptors, Dopamine D2 / metabolism*
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism*
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Serotonin Antagonists / pharmacokinetics
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Spiperone / metabolism
Substances
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Antipsychotic Agents
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Carbazoles
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Dopamine Antagonists
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Indoles
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Receptor, Serotonin, 5-HT2A
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Receptors, Dopamine D2
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Receptors, Serotonin
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Serotonin Antagonists
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Spiperone
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Ketanserin