Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates

Z Zídek; D Franková; A Holý

doi:10.1080/15257779908041612

Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):959-61. doi: 10.1080/15257779908041612.

Authors

Z Zídek¹, D Franková, A Holý

Affiliation

¹ Institute of Pharmacology, Academy of Sciences, Prague, Czech Republic.

PMID: 10432720
DOI: 10.1080/15257779908041612

Abstract

Several antiviral acyclic nucleotide analogues activate expression of genes for cytokines, such as TNF-alpha, IL-10 in macrophages and IFN-gamma in splenocytes. This is an underlying mechanism for substantially enhanced production of nitric oxide generated by IFN-gamma. More lipophilic prodrugs, bis-POM-PMEA and bis-POC-PMPA, are cytocidal for macrophages and thus inhibit nitric oxide formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Interferon-gamma / biosynthesis*
Interleukin-10 / biosynthesis*
Macrophages / drug effects
Macrophages / metabolism
Mice
Nitric Oxide / biosynthesis*
Nucleotides / pharmacology*
Rats
Tumor Necrosis Factor-alpha / biosynthesis*

Substances

Nucleotides
Tumor Necrosis Factor-alpha
Interleukin-10
Nitric Oxide
Interferon-gamma