Abstract
Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.
MeSH terms
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Anti-HIV Agents / pharmacology
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Base Sequence
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Cell Line
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DNA Primers
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Drug Resistance, Microbial
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HIV-1 / drug effects*
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HIV-1 / enzymology
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HIV-1 / genetics
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Humans
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Microbial Sensitivity Tests
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Phenotype
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Reverse Transcriptase Inhibitors / pharmacology
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Reverse Transcriptase Polymerase Chain Reaction
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Stavudine / analogs & derivatives*
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Stavudine / pharmacology
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Thymidine Kinase / genetics
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Zidovudine / pharmacology*
Substances
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Anti-HIV Agents
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DNA Primers
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Reverse Transcriptase Inhibitors
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Zidovudine
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Stavudine
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Thymidine Kinase