Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):933-6. doi: 10.1080/15257779908041602.

Abstract

Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.

MeSH terms

  • Anti-HIV Agents / pharmacology
  • Base Sequence
  • Cell Line
  • DNA Primers
  • Drug Resistance, Microbial
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • HIV-1 / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Phenotype
  • Reverse Transcriptase Inhibitors / pharmacology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stavudine / analogs & derivatives*
  • Stavudine / pharmacology
  • Thymidine Kinase / genetics
  • Zidovudine / pharmacology*

Substances

  • Anti-HIV Agents
  • DNA Primers
  • Reverse Transcriptase Inhibitors
  • Zidovudine
  • Stavudine
  • Thymidine Kinase