L-purine nucleosides as selective antimalarials

A M Gero; G Perrone; D M Brown; S T Hall; C K Chu

doi:10.1080/15257779908041593

L-purine nucleosides as selective antimalarials

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):885-9. doi: 10.1080/15257779908041593.

Authors

A M Gero¹, G Perrone, D M Brown, S T Hall, C K Chu

Affiliation

¹ School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia.

PMID: 10432703
DOI: 10.1080/15257779908041593

Abstract

L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Deaminase / metabolism*
Animals
Antimalarials / pharmacokinetics
Antimalarials / pharmacology*
Chromatography, High Pressure Liquid
Erythrocytes / parasitology
Plasmodium falciparum / enzymology
Purine Nucleosides / pharmacokinetics
Purine Nucleosides / pharmacology*

Substances

Antimalarials
Purine Nucleosides
Adenosine Deaminase