Simple and stereoselective syntheses of nucleoside analogues with a benzo[c]furan glycone moiety

D F Ewing; N Fahmi; G Mackenzie; A Pranzo

doi:10.1080/15257779908041494

Simple and stereoselective syntheses of nucleoside analogues with a benzo[c]furan glycone moiety

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):559-63. doi: 10.1080/15257779908041494.

Authors

D F Ewing¹, N Fahmi, G Mackenzie, A Pranzo

Affiliation

¹ Department of Chemistry, University of Hull, UK.

PMID: 10432646
DOI: 10.1080/15257779908041494

Abstract

A series of d4T analogues have been synthesised in which the 2',3'-didehydro-2',3'-dideoxyribose moiety is replaced by a benzo[c]furan core. A simple strategy has been developed to access a range of compounds for biological screening. In addition, a stereoselective approach has been achieved with view to permit more detailed studies.

MeSH terms

Anti-HIV Agents / chemical synthesis
Anti-HIV Agents / chemistry
Benzofurans / chemistry*
Reverse Transcriptase Inhibitors / chemical synthesis
Reverse Transcriptase Inhibitors / chemistry
Stavudine / analogs & derivatives
Stavudine / chemical synthesis*
Stereoisomerism

Substances

Anti-HIV Agents
Benzofurans
Reverse Transcriptase Inhibitors
Stavudine
benzofuran