Apicomplexan plastids as drug targets

Trends Microbiol. 1999 Aug;7(8):328-33. doi: 10.1016/s0966-842x(99)01547-4.

Abstract

Prokaryotic metabolic pathways in the relict plastid of apicomplexan parasites make this organelle a promising target for drug development. The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antiprotozoal Agents / pharmacology*
  • Apicomplexa / drug effects*
  • Apicomplexa / genetics*
  • Herbicides / pharmacology*
  • Plastids / drug effects*
  • Plastids / genetics
  • Plastids / metabolism
  • Protozoan Infections / drug therapy
  • Protozoan Infections / parasitology

Substances

  • Antiprotozoal Agents
  • Herbicides