Abstract
Chlorambucil derivatives involving alkyl 2-aminodeoxy sugars have been synthesized in good yield by coupling the chlorambucil moiety to positions C-2 or C-3 of the sugar, directly or via a spacer. The starting material was easily available from 2-acetamido-2-deoxy-D-glucose. The final compounds were tested for cytotoxicity, and some of those that presented the best results were studied for inhibition of cell proliferation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Sugars / administration & dosage*
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Amino Sugars / chemistry
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Amino Sugars / toxicity
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Animals
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Antineoplastic Agents, Alkylating / administration & dosage*
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Antineoplastic Agents, Alkylating / chemistry
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Antineoplastic Agents, Alkylating / toxicity
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Carcinoma / pathology
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Cell Division / drug effects
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Chlorambucil / administration & dosage*
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Chlorambucil / chemistry
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Chlorambucil / toxicity
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Deoxy Sugars / administration & dosage*
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Deoxy Sugars / chemistry
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Deoxy Sugars / toxicity
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Drug Carriers
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Ethanolamine / chemistry
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Female
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Humans
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Leukemia, Promyelocytic, Acute / pathology
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Mice
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Molecular Structure
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Nasopharyngeal Neoplasms / pathology
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Tumor Cells, Cultured / drug effects
Substances
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Amino Sugars
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Antineoplastic Agents, Alkylating
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Deoxy Sugars
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Drug Carriers
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Chlorambucil
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Ethanolamine