Migraine and other functional disorders are common and often difficult to treat. Alternative treatment modalities are clearly warranted and gain more widespread acceptance. Psychofonia is a new form of music therapy for treating migraine patients. For each patient an individualized sound pattern is created based on his individual EEG by using computer technology. In a cohort study we investigated prospectively 55 migraine patients treated with this EEG-based music therapy. 56% of the patients showed an improvement of at least 50% of their symptoms after a twelve months treatment period. Our results suggest that this form of music therapy is effective in treating migraine patients and should be studied in a prospective, randomized, controlled trial.