Alcohol consumption and gallstones are the most common causes of acute pancreatitis in developed countries. However, some episodes of acute pancreatitis have being regarded "idiopathic" once blood samples have been analyzed and diagnostic procedures (abdominal ultrasonography, CT and ERCP) have been performed. Sphincter of Oddi (SO) dysfunction is a rare entity that may be involved in the development of recurrent acute pancreatitis. SO manometry is the first option to investigate SO dysfunction. A recurrent idiopathic pancreatitis case in a young patient is presented. The manometric study revealed SO dysfunction, and oral nidefipine 10 mg was started. After a 12-months follow-up undergoing this therapy, the patient remains asymptomatic.