Interaction of cyanine dyes with nucleic acids. XII.beta-substituted carbocyanines as possible fluorescent probes for nucleic acids detection

S M Yarmoluk; V B Kovalska; S S Lukashov; Y L Slominskii

doi:10.1016/s0960-894x(99)00253-x

Interaction of cyanine dyes with nucleic acids. XII.beta-substituted carbocyanines as possible fluorescent probes for nucleic acids detection

Bioorg Med Chem Lett. 1999 Jun 21;9(12):1677-8. doi: 10.1016/s0960-894x(99)00253-x.

Authors

S M Yarmoluk¹, V B Kovalska, S S Lukashov, Y L Slominskii

Affiliation

¹ Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv.

PMID: 10397499
DOI: 10.1016/s0960-894x(99)00253-x

Abstract

Results of investigations of fluorescent properties of a beta-substituted carbocyanine and its complexes with nucleic acids in comparison with those for the unsubstituted dye are presented. Carbocyanine substituted in polymethine chain has shown promising properties for use as a fluorescent probe in homogeneous systems of nucleic acids detection.

MeSH terms

Carbocyanines / chemical synthesis
Carbocyanines / chemistry*
DNA / analysis
DNA / chemistry
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
Magnetic Resonance Spectroscopy
Nucleic Acids / analysis*
Nucleic Acids / chemistry
RNA / analysis
RNA / chemistry

Substances

Carbocyanines
Fluorescent Dyes
Nucleic Acids
cyan 2
cyan 46
RNA
DNA