Tetrin C, a new glycosylated polyene macrolide antibiotic produced by Streptomyces sp. GK9244

G Ryu; W C Choi; S Hwang; W H Yeo; C S Lee; S K Kim

doi:10.1021/np9805645

Tetrin C, a new glycosylated polyene macrolide antibiotic produced by Streptomyces sp. GK9244

J Nat Prod. 1999 Jun;62(6):917-9. doi: 10.1021/np9805645.

Authors

G Ryu¹, W C Choi, S Hwang, W H Yeo, C S Lee, S K Kim

Affiliation

¹ Korea Ginseng & Tobacco Research Institute, 302 Shinsung-dong Yousung-ku, Taejon, 305-345, Korea.

PMID: 10395521
DOI: 10.1021/np9805645

Abstract

A new antifungal 26-membered polyene macrolide, tetrin C (1), has been isolated from Streptomyces sp. GK9244. Its structure has been determined by interpretation of NMR data. Compound 1 exhibited antifungal activity against Mortierella ramannianus (MIC, 5 microg/mL).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Antifungal Agents / biosynthesis
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Chromatography, High Pressure Liquid
Fungi / drug effects
Macrolides*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Spectrophotometry, Ultraviolet
Streptomyces / chemistry*
Streptomyces / metabolism

Substances

Anti-Bacterial Agents
Antifungal Agents
Macrolides
tetrin C