Various kinds of works of 6-11th-form schoolchildren on Macintosh computers were physiologically and hygienically assessed at the lesson of information science and computer engineering (ISCE), as well as typing. The fatigue of a visual analyzer was due to the time of looking through the data available on the display; the adverse changes of the higher nervous activity depends on the complexity of educational materials and the intensity of work on a computer. Three-hour studies in ISCE should be excluded from the time able of lessons as they do not meet hygienic requirements.