Synthesis of 25-aminosterols, new antifungal agents

P Beuchet; M Dherbomez; L Elkiel; G Charles; Y Letourneux

doi:10.1016/s0960-894x(99)00233-4

Synthesis of 25-aminosterols, new antifungal agents

Bioorg Med Chem Lett. 1999 Jun 7;9(11):1599-600. doi: 10.1016/s0960-894x(99)00233-4.

Authors

P Beuchet¹, M Dherbomez, L Elkiel, G Charles, Y Letourneux

Affiliation

¹ Laboratoire de Synthèse et Etude de Substances Naturelles à Activités Biologiques, Université de La Rochelle, France.

PMID: 10386943
DOI: 10.1016/s0960-894x(99)00233-4

Abstract

25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity with MIC value of 4 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Candida albicans / drug effects
Cholesterol / analogs & derivatives*
Cholesterol / chemical synthesis
Inhibitory Concentration 50
Lanosterol / analogs & derivatives*
Lanosterol / chemical synthesis
Models, Chemical

Substances

25-aminocholesterol
Antifungal Agents
25-aminolanosterol
Lanosterol
Cholesterol