Opposite effects of inhibitory and excitatory neurosteroids on [3H]dopamine release from rat nucleus accumbens

L Jaworska-Feil; B Budziszewska; M Leśkiewicz; W Lasoń

Opposite effects of inhibitory and excitatory neurosteroids on [3H]dopamine release from rat nucleus accumbens

Pol J Pharmacol. 1998 Nov-Dec;50(6):449-52.

Authors

L Jaworska-Feil¹, B Budziszewska, M Leśkiewicz, W Lasoń

Affiliation

¹ Department of Endocrinology, Polish Academy of Sciences, Kraków, Poland.

PMID: 10385928

Abstract

Neurosteroids with GABAA receptor antagonistic properties increase K(+)-evoked [3H]dopamine release from rat nucleus accumbens slices, whereas neurosteroid positive modulators of GABAA exert an opposite effect.

MeSH terms

Animals
Dopamine / metabolism*
GABA Modulators / pharmacology*
In Vitro Techniques
Male
Nucleus Accumbens / metabolism*
Pregnanediones / pharmacology*
Pregnanolone / pharmacology*
Progesterone / pharmacology*
Rats
Rats, Wistar

Substances

GABA Modulators
Pregnanediones
Progesterone
Pregnanolone
Dopamine