The role of Chlamydia trachomatis infection in cervical cancer development

J Markowska; N Fischer; V Filas; Z Fischer; J Breborowicz; M Markowski

The role of Chlamydia trachomatis infection in cervical cancer development

Eur J Gynaecol Oncol. 1999;20(2):144-6.

Authors

J Markowska¹, N Fischer, V Filas, Z Fischer, J Breborowicz, M Markowski

Affiliation

¹ Oncology K. Marcinkowski University of Medicine Sciences, Poznań, Poland.

PMID: 10376435

Abstract

Previous Chlamydia trachomatis infection elevates expression of: 1. TGFalpha in CIN I, CIN II, CIN III; 2. HPV 16 in CIN I, CIN II, CIN III and invasive carcinoma; 3. Ki 67 in CIN III and invasive carcinoma. Chronic Chlamydial infection is very often associated with cervical hypertrophy.

MeSH terms

Case-Control Studies
Chlamydia Infections / complications*
Chlamydia trachomatis / isolation & purification*
ErbB Receptors / metabolism
Female
Humans
Ki-67 Antigen / metabolism
Papillomaviridae / isolation & purification
Transforming Growth Factor alpha / metabolism
Uterine Cervical Neoplasms / etiology*
Uterine Cervical Neoplasms / microbiology*
Uterine Cervical Neoplasms / pathology

Substances

Ki-67 Antigen
Transforming Growth Factor alpha
ErbB Receptors