Abstract
We investigated the Gln --> Arg 191 polymorphism in paraoxonase (PON1) in St. Petersburg population, in three clinically differentiated groups of patients with Parkinson's disease (PD) and in the symptomatic tremor group. A new approach for Gln --> Arg 191 PON1 polymorphism genotyping is suggested. No significant differences in the groups studies as compared to the controls was observed.
MeSH terms
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Aged
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Alleles
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Amino Acid Substitution
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Arginine / genetics*
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Aryldialkylphosphatase
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Base Sequence
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DNA / genetics
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DNA / metabolism
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DNA Restriction Enzymes / metabolism
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Deoxyribonucleases, Type I Site-Specific
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Esterases / genetics*
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Gene Frequency
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Genotype
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Glutamine / genetics*
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Humans
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Middle Aged
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Parkinson Disease / enzymology
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Parkinson Disease / genetics*
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Polymorphism, Genetic
Substances
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Glutamine
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DNA
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Arginine
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Esterases
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DNA Restriction Enzymes
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Deoxyribonucleases, Type I Site-Specific
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Aryldialkylphosphatase
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PON1 protein, human