Vesicle formation from hexasubstituted cyclophosphazenic derivatives

B Baroli; G Delogu; A M Fadda; G Podda; C Sinico

doi:10.1016/s0378-5173(99)00024-1

Vesicle formation from hexasubstituted cyclophosphazenic derivatives

Int J Pharm. 1999 Jun 25;183(2):101-7. doi: 10.1016/s0378-5173(99)00024-1.

Authors

B Baroli¹, G Delogu, A M Fadda, G Podda, C Sinico

Affiliation

¹ Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, Università di Cagliari, Via Ospedale 72, 09124, Cagliari, Italy.

PMID: 10361160
DOI: 10.1016/s0378-5173(99)00024-1

Abstract

Hexakis[butoxytris(ethoxy)]cyclophosphazene (3a), hexakis[dodecyloxytetrakis (ethoxy)]cyclophosphazene (3b) and hexakis[hexadecyloxyeicosanekis(ethoxy)]cyclophosphazene+ ++ (3c) were synthesised and their ability to form niosomes was studied. All synthesised compounds in the presence of cholesterol were shown to form vesicles, which aggregated strongly. To prevent aggregation, dicetylphosphate was used. The capacity of the sonicated and unsonicated niosomes to encapsulate hydrophile and lipophile molecules was also studied using carboxyfluorescein and diphenylhexatriene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cholesterol / chemistry*
Membranes, Artificial*
Microscopy, Electron
Organophosphorus Compounds / chemistry*
Sonication

Substances

Membranes, Artificial
Organophosphorus Compounds
Cholesterol