The prevalence of hepatitis C virus (HCV) is studied in different age and risk groups in the city of Vladimir and the genotypes of the virus circulating at this territory are determined. Anti-HCV are detected in 2.4% donors and 1.4% pregnant women. Population immunity to HCV gradually increases with age. AntiHCV are detected in 0.9% children aged 3-6 years, in 1.8% in the group aged 20-29 years, and in 2.9% in the group aged 30-39 years. Medical workers, mental inpatients, hematological patients, patients hospitalized at hemoperfusion departments, and imprisoned subjects were referred to groups at risk of HCV infection: antiHCV were detected in 3.9, 5.4, 13.8, 53.6, and 24.5% of these groups, respectively. Genotype 1b predominates in the structure of HCV genotypes circulating in Vladimir: 72.9% in all examined population groups. In addition to this genotype, genotypes 2a, 2b, and 3a were detected (2.9, 2.9, and 15.7%, respectively). Genotype 3a was the most incident in children aged 0-14 years.