[The characteristics of the neuropsychotropic activity of bromantane in laboratory animals]

Eksp Klin Farmakol. 1999 Mar-Apr;62(2):3-6.
[Article in Russian]

Abstract

Bromantan [N-2-(para-(bromphenyl)-N-2-(aminoadamantan)] possesses psychostimulating activity in experiments on animals. With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect. Bromantan is characterized by a positive effect on mnemonic processes and on obtaining the results of complex operant activity in rats.

Publication types

  • Comparative Study

MeSH terms

  • Amantadine / analogs & derivatives*
  • Amantadine / pharmacology
  • Amantadine / toxicity
  • Animals
  • Behavior, Animal / drug effects
  • Catalepsy / chemically induced
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Electroencephalography / drug effects
  • Lethal Dose 50
  • Male
  • Mice
  • Motor Activity / drug effects
  • Psychotropic Drugs / pharmacology*
  • Psychotropic Drugs / toxicity
  • Rabbits
  • Rats
  • Time Factors

Substances

  • Psychotropic Drugs
  • Amantadine
  • bromantane